Foxp2^tm1.2Sfis
Targeted Allele Detail

Summary

• Symbol: Foxp2^tm1.2Sfis
• Name: forkhead box P2; targeted mutation 1.2, Simon E Fisher
• MGI ID: MGI:3723630
• Synonyms: Foxp2^delta12-14
• Gene: Foxp2 Location: Chr6:14901348-15441976 bp, + strand Genetic Position: Chr6, 6.49 cM, cytoband A2
• Alliance: Foxp2^tm1.2Sfis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125023
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 12 through 14 were removed by cre-mediated recombination. The absence of protein product was confirmed by western blot analysis on the striatal precursor region of E16.5 embryos using antibodies recognizing the N-terminal region of the protein. (J:125023)

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxp2 Mutation: 52 strains or lines available

References

• Original: J:125023 French CA, et al., Generation of mice with a conditional Foxp2 null allele. Genesis. 2007 Jul;45(7):440-6
• All: 2 reference(s)