Plpp3^tm3.1Stw
Targeted Allele Detail

Summary

• Symbol: Plpp3^tm3.1Stw
• Name: phospholipid phosphatase 3; targeted mutation 3.1, Colin L Stewart
• MGI ID: MGI:3723634
• Synonyms: Ppap2b^deltafloxed
• Gene: Plpp3 Location: Chr4:105014544-105089961 bp, + strand Genetic Position: Chr4, 49.18 cM
• Alliance: Plpp3^tm3.1Stw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125025
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 3 and 4 were removed by cre-mediated recombination. Recombination was confirmed by Southern blot. These exons encode the second outer loop that is essential for catalytic activity and the tripeptide RGA thought to function in cell-cell interactions. This allele is expected to behave as a null. (J:125025)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plpp3 Mutation: 32 strains or lines available

References

• Original: J:125025 Escalante-Alcalde D, et al., Generation of a conditional Ppap2b/Lpp3 null allele. Genesis. 2007 Jul;45(7):465-9
• All: 3 reference(s)