Aqp7^tm1Chan
Targeted Allele Detail

Summary

• Symbol: Aqp7^tm1Chan
• Name: aquaporin 7; targeted mutation 1, Lawrence Chan
• MGI ID: MGI:3723644
• Synonyms: Aqp7^-
• Gene: Aqp7 Location: Chr4:41033074-41048139 bp, - strand Genetic Position: Chr4, 20.83 cM, cytoband B1
• Alliance: Aqp7^tm1Chan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125011
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The second half of exon 3 and part of intron 4 were replaced with an IRES-lacZ-neo cassette. Insertion of the locus was confirmed by PCR and RT-PCR was used to confirm the absence of transcripts in islet and pancreas tissue. (J:125011)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aqp7 Mutation: 24 strains or lines available

References

• Original: J:125011 Matsumura K, et al., Aquaporin 7 Is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion. Mol Cell Biol. 2007 Sep;27(17):6026-37
• All: 1 reference(s)