Plpp3^tm2Stw
Targeted Allele Detail

Summary

• Symbol: Plpp3^tm2Stw
• Name: phospholipid phosphatase 3; targeted mutation 2, Colin L Stewart
• MGI ID: MGI:3723646
• Synonyms: Ppap2b^lacZ
• Gene: Plpp3 Location: Chr4:105014544-105089961 bp, + strand Genetic Position: Chr4, 49.18 cM
• Alliance: Plpp3^tm2Stw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142493
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Three stop codons in three framse followed by an IRES-lacZ cassette and a floxed neo cassette were inserted in exon 3 via homologous recombination. The insertion of this construct disrupts the protein between the C1 and C2 domains essential for catalytic activity. (J:142493)

Expression

In Mice Carrying this Mutation:	141 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plpp3 Mutation: 32 strains or lines available

References

• Original: J:142493 Escalante-Alcalde D, et al., Generation of a reporter-null allele of Ppap2b/Lpp3 and its expression during embryogenesis. Int J Dev Biol. 2009;53(1):139-147
• All: 3 reference(s)