Paqr3^tm1Ychn
Targeted Allele Detail

Summary

• Symbol: Paqr3^tm1Ychn
• Name: progestin and adipoQ receptor family member III; targeted mutation 1, Yan Chen
• MGI ID: MGI:3757569
• Synonyms: RKTG^-
• Gene: Paqr3 Location: Chr5:97230188-97259455 bp, - strand Genetic Position: Chr5, 47.29 cM
• Alliance: Paqr3^tm1Ychn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124964
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced by a neomycin selection cassette that caused a downstream frameshift in sequences encoding the transmembrane domains of this protein. RT-PCR analysis of liver RNA indicated that a truncated transcript is produced from this allele. (J:124964)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Paqr3 Mutation: 22 strains or lines available

References

• Original: J:124964 Feng L, et al., Spatial regulation of Raf kinase signaling by RKTG. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14348-53
• All: 7 reference(s)