Abca3^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Abca3^tm1Dgen
• Name: ATP-binding cassette, sub-family A member 3; targeted mutation 1, Deltagen
• MGI ID: MGI:3757572
• Gene: Abca3 Location: Chr17:24570997-24629178 bp, + strand Genetic Position: Chr17, 12.38 cM, cytoband A3.3
• Alliance: Abca3^tm1Dgen page

Lung abnormalities in Abca3^tm1Dgen/Abca3⁺, and Abca3^tm1Dgen/Abca3^tm1Dgen mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124809
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An IRES-lacZ-neo cassette was inserted into the open reading frame replacing 70 bp of protein coding sequence. Homologous recombination was confirmed by PCR. Absence of protein was confirmed by immunohistochemistrry on lung tissue. (J:124809)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abca3 Mutation: 92 strains or lines available

References

• Original: J:124809 Cheong N, et al., ABCA3 is critical for lamellar body biogenesis in vivo. J Biol Chem. 2007 Aug 17;282(33):23811-7
• All: 1 reference(s)