Ntng1^tm1Ito
Targeted Allele Detail

Summary

• Symbol: Ntng1^tm1Ito
• Name: netrin G1; targeted mutation 1, Shigeyoshi Itohara
• MGI ID: MGI:3757573
• Synonyms: Ntng1 KO, Ntng1^tm1(lacZ)Ito
• Gene: Ntng1 Location: Chr3:109687356-110051327 bp, - strand Genetic Position: Chr3, 48.47 cM, cytoband G1
• Alliance: Ntng1^tm1Ito page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124961
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A N-lacZ reporter gene and a loxP-flanked neomycin resistance cassette was inserted in frame to the initation codon of this gene. Mice were crossed with Cre recombinase transgenic mice to remove the resistance cassette. Northern blot and immunohistochemical analysis on brains of homozygous mice confirmed lack of expression of this gene with no compensatory increases in expression of the related Ntng2 gene. (J:124961)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ntng1 Mutation: 53 strains or lines available

References

• Original: J:124961 Nishimura-Akiyoshi S, et al., Axonal netrin-Gs transneuronally determine lamina-specific subdendritic segments. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14801-6
• All: 6 reference(s)