Ntng2^tm1Ito
Targeted Allele Detail

Summary

• Symbol: Ntng2^tm1Ito
• Name: netrin G2; targeted mutation 1, Shigeyoshi Itohara
• MGI ID: MGI:3757587
• Synonyms: Ntng2 KO
• Gene: Ntng2 Location: Chr2:29084738-29138111 bp, - strand Genetic Position: Chr2, 19.57 cM, cytoband A3
• Alliance: Ntng2^tm1Ito page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124961
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-flanked neomycin resistance cassette replaced part of the upstream UTR and coding region of this gene. Mice were crossed with Cre recombinase transgenic mice to remove the neo cassette. Northern blot and immunohistochemical analysis on brains of homozygous mice confirmed lack of expression of this gene with no compensatory increases in expression of the related Ntng1 gene. (J:124961)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ntng2 Mutation: 34 strains or lines available

References

• Original: J:124961 Nishimura-Akiyoshi S, et al., Axonal netrin-Gs transneuronally determine lamina-specific subdendritic segments. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14801-6
• All: 4 reference(s)