Kcnk9^tm1Wwis
Targeted Allele Detail

Summary

• Symbol: Kcnk9^tm1Wwis
• Name: potassium channel, subfamily K, member 9; targeted mutation 1, W Wisden
• MGI ID: MGI:3757590
• Synonyms: Kcnk9^tm1Sgb, TASK3-KO
• Gene: Kcnk9 Location: Chr15:72372938-72418189 bp, - strand Genetic Position: Chr15, 33.46 cM
• Alliance: Kcnk9^tm1Wwis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124944
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: 4 copies of a selection cassette containing a loxP flanked exon 1 and a frt flanked neomycin resistance gene inserted in tandem into exon 1. In situ hybridization on brains of homozygotes indicated that the multiple repeats disrupted gene expression. Expression of adjacent genes was not affected as determined by in situ hybridization. (J:124944)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnk9 Mutation: 17 strains or lines available

References

• Original: J:124944 Brickley SG, et al., TASK-3 two-pore domain potassium channels enable sustained high-frequency firing in cerebellar granule neurons. J Neurosci. 2007 Aug 29;27(35):9329-40
• All: 8 reference(s)