Ophn1^tm2Bill
Targeted Allele Detail

Summary

• Symbol: Ophn1^tm2Bill
• Name: oligophrenin 1; targeted mutation 2, Pierre Billuart
• MGI ID: MGI:3757642
• Synonyms: Ophn1 floxed allele
• Gene: Ophn1 Location: ChrX:97597883-97934631 bp, - strand Genetic Position: ChrX, 42.94 cM, cytoband C2
• Alliance: Ophn1^tm2Bill page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124943
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A cassette flanked by mutant loxP sites was constructed with the entire coding sequence of the target gene oriented in one direction and a second "marker" gene orientated in the opposite direction. This construct was inserted into the first coding exon so that gene expression was simultaneously disrupted and rescued by the inserted cassette. The sequence between the mutant loxP alleles is inverted upon Cre recombinase activity, leading to inactivation of the gene coding sequence and expression of the marker gene. (J:124943)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ophn1 Mutation: 12 strains or lines available

References

• Original: J:124943 Khelfaoui M, et al., Loss of X-linked mental retardation gene oligophrenin1 in mice impairs spatial memory and leads to ventricular enlargement and dendritic spine immaturity. J Neurosci. 2007 Aug 29;27(35):9439-50
• All: 1 reference(s)