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Ophn1tm2Bill
Targeted Allele Detail
Summary
Symbol: Ophn1tm2Bill
Name: oligophrenin 1; targeted mutation 2, Pierre Billuart
MGI ID: MGI:3757642
Synonyms: Ophn1 floxed allele
Gene: Ophn1  Location: ChrX:97597883-97934631 bp, - strand  Genetic Position: ChrX, 42.94 cM, cytoband C2
Alliance: Ophn1tm2Bill page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:124943
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA cassette flanked by mutant loxP sites was constructed with the entire coding sequence of the target gene oriented in one direction and a second "marker" gene orientated in the opposite direction. This construct was inserted into the first coding exon so that gene expression was simultaneously disrupted and rescued by the inserted cassette. The sequence between the mutant loxP alleles is inverted upon Cre recombinase activity, leading to inactivation of the gene coding sequence and expression of the marker gene. (J:124943)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ophn1 Mutation:  12 strains or lines available
References
Original:  J:124943 Khelfaoui M, et al., Loss of X-linked mental retardation gene oligophrenin1 in mice impairs spatial memory and leads to ventricular enlargement and dendritic spine immaturity. J Neurosci. 2007 Aug 29;27(35):9439-50
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory