Dlg5^tm1Vv
Targeted Allele Detail

Summary

• Symbol: Dlg5^tm1Vv
• Name: discs large MAGUK scaffold protein 5; targeted mutation 1, Valeri Vasioukhin
• MGI ID: MGI:3757646
• Gene: Dlg5 Location: Chr14:24184021-24295988 bp, - strand Genetic Position: Chr14, 14.26 cM
• Alliance: Dlg5^tm1Vv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124940
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 2 was disrupted with an IRES-beta-geo cassette, creating a stop codon 25 amino acids after the translation initiation site. Northen and Western blot analysis on brains from homozygotes demonstrated complete absence of gene expression. (J:124940)

Expression

In Mice Carrying this Mutation:	113 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dlg5 Mutation: 126 strains or lines available

References

• Original: J:124940 Nechiporuk T, et al., Failure of epithelial tube maintenance causes hydrocephalus and renal cysts in dlg5(-/-) mice. Dev Cell. 2007 Sep;13(3):338-50
• All: 5 reference(s)