Igh^tm2.1Hws
Targeted Allele Detail

Summary

• Symbol: Igh^tm2.1Hws
• Name: immunoglobulin heavy chain complex; targeted mutation 2.1, Harry W Schroeder Jr
• MGI ID: MGI:3757674
• Synonyms: deltaD-iD
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124421
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intergenic deletion
• Igh^tm2Hws mice were crossed with Cre recombinase transgenic mice to delete the DH locus. (J:124421)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 44 strains or lines available

References

• Original: J:124421 Ippolito GC, et al., Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production. J Exp Med. 2006 Jun 12;203(6):1567-78
• All: 5 reference(s)