Il24^tm1Dnax
Targeted Allele Detail

Summary

• Symbol: Il24^tm1Dnax
• Name: interleukin 24; targeted mutation 1, DNAX Research Institute of Cellular and Molecular Biology
• MGI ID: MGI:3757698
• Synonyms: IL-24 ^-
• Gene: Il24 Location: Chr1:130809801-130815153 bp, - strand Genetic Position: Chr1, 56.89 cM, cytoband E4
• Alliance: Il24^tm1Dnax page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124591
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a loxP-flanked neo cassette. Transient expression of Cre recombinase removed the neo cassette. (J:124591)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il24 Mutation: 22 strains or lines available

References

• Original: J:124591 Chan JR, et al., IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. J Exp Med. 2006 Nov 27;203(12):2577-87
• All: 2 reference(s)