Tg(Myh6-tTA)55Rbns
Transgene Detail

Summary

• Symbol: Tg(Myh6-tTA)55Rbns
• Name: transgene insertion 55, Jeffrey Robbins
• MGI ID: MGI:3757936
• Synonyms: alpha-MHC-tTA
• Transgene: Tg(Myh6-tTA)55Rbns Location: unknown
• Alliance: Tg(Myh6-tTA)55Rbns page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: This transgene consists of the tetracycline transactivator (a chimeric tTA fusion protein of the Tn10 Tet resistance operon in E.coli and the carboxy-terminal portion of the transactivator protein from herpes simplex virus -VP16) under the control of the cardiac specific mouse alpha myosin heavy chain. Although transgene protein expression is not detected in the heart via Western blot, when transgenics are crossed with Tg(tetop-lacZ)2Mam, uniform and robust expression of lacZ is seen in the hearts, indicating that very low levels of tTA protein are present to induce lacZ expression. (J:125131)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:125131 Sanbe A, et al., Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy chain promoter. Circ Res. 2003 Apr 4;92(6):609-16
• All: 45 reference(s)