Tg(Myh6-rtTA2S*M2)216Rbns
Transgene Detail

Summary

• Symbol: Tg(Myh6-rtTA2S*M2)216Rbns
• Name: transgene insertion 216, Jeffrey Robbins
• MGI ID: MGI:3757939
• Synonyms: S2M2FFF
• Transgene: Tg(Myh6-rtTA2S*M2)216Rbns Location: unknown
• Alliance: Tg(Myh6-rtTA2S*M2)216Rbns page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: This transgene consists of an optimized reverse tetracycline transactivator under the control of the mouse alpha myosin heavy chain. rtTA is optimized by changing 5 amino acids (S12G, E19G, A56P, D148E, and H179R referred as M2) in the synthesized (S2) construct and linking it to 3 repeats of a 12-amino-acid sequence, FFF, which is the minimum activator domain of VP16. The transgene is expressed in the heart only when doxycycline is present. (J:125131)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:125131 Sanbe A, et al., Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy chain promoter. Circ Res. 2003 Apr 4;92(6):609-16
• All: 2 reference(s)