Gnptab^{Gt(OST97730)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Gnptab^{Gt(OST97730)Lex}
• Name: N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits; gene trap OST97730, Lexicon Genetics
• MGI ID: MGI:3757945
• Synonyms: Gnptab^-
• Gene: Gnptab Location: Chr10:88215130-88283186 bp, + strand Genetic Position: Chr10, 43.86 cM
• Alliance: Gnptab^{Gt(OST97730)Lex} page

Mutation origin

• Mutant Cell Line: OST97730
• Germline Transmission: Earliest citation of germline transmission: J:124928
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap vector VICTR48 was inserted into the first intron, disrupting translation and resulting in a truncation of the alpha/beta precursor after 39 amino acids in the encoded protein. (J:124928)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST97730	CG524132 ; (MGI Seq Detail)	3' RACE	Chr10:88250255-88250424 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  4 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gnptab Mutation: 78 strains or lines available

References

• Original: J:124928 Lee WS, et al., Murine UDP-GlcNAc:Lysosomal Enzyme N-Acetylglucosamine-1-phosphotransferase Lacking the {gamma}-Subunit Retains Substantial Activity toward Acid Hydrolases. J Biol Chem. 2007 Sep 14;282(37):27198-203
• All: 12 reference(s)