Gnptg^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Gnptg^tm1Lex
• Name: N-acetylglucosamine-1-phosphotransferase, gamma subunit; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3757947
• Synonyms: Gnptg^tm1Korn
• Gene: Gnptg Location: Chr17:25452305-25459098 bp, - strand Genetic Position: Chr17, 12.53 cM
• Alliance: Gnptg^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124928
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Exons 4 through 11 were deleted resulting in truncation of the gamma-subunit after 59 amino acids. (J:124928)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gnptg Mutation: 10 strains or lines available

References

• Original: J:124928 Lee WS, et al., Murine UDP-GlcNAc:Lysosomal Enzyme N-Acetylglucosamine-1-phosphotransferase Lacking the {gamma}-Subunit Retains Substantial Activity toward Acid Hydrolases. J Biol Chem. 2007 Sep 14;282(37):27198-203
• All: 4 reference(s)