Dbx1^tm1(DTA)Apie
Targeted Allele Detail

Summary

• Symbol: Dbx1^tm1(DTA)Apie
• Name: developing brain homeobox 1; targeted mutation 1, Alessandra Pierani
• MGI ID: MGI:3757953
• Synonyms: Dbx1^DTA, Dbx1^{IRES-loxP-Stop-loxP-DTA}, Dbx1^{loxP-stop-loxP-DTA}
• Gene: Dbx1 Location: Chr7:49281247-49286583 bp, - strand Genetic Position: Chr7, 31.44 cM
• Alliance: Dbx1^tm1(DTA)Apie page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101434
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: An IRES floxed PGK-neo cassette and the diphtheria toxin (DTA) gene were inserted in the downstream untranslated portion of the gene. Multiple stop codons in the PGK-neo cassette prevent translation read-through of the diphtheria toxin gene. Functional DTA is expressed upon Cre-mediated recombination. (J:101434)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dbx1 Mutation: 25 strains or lines available

References

• Original: J:101434 Bielle F, et al., Multiple origins of Cajal-Retzius cells at the borders of the developing pallium. Nat Neurosci. 2005 Aug;8(8):1002-12
• All: 13 reference(s)