Tbx1^tm6(cre)Bld
Targeted Allele Detail

Summary

• Symbol: Tbx1^tm6(cre)Bld
• Name: T-box 1; targeted mutation 6, Antonio Baldini
• MGI ID: MGI:3757964
• Synonyms: Tbx1^Cre
• Gene: Tbx1 Location: Chr16:18399729-18409412 bp, - strand Genetic Position: Chr16, Syntenic
• Alliance: Tbx1^tm6(cre)Bld page

Failure of inner ear morphogenesis in Tbx1^tm1Bld/Tbx1^tm1Bld mice at E14.5 and partial rescue of inner ear morphogenesis in Tbx1^tm6(cre)Bld/Tbx1^tm1Bld Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/ Gt(ROSA)26Sor⁺ mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125024
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Tbx1^tm6(cre)Bld expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tbx1 (MGI:98493)

• Mutation details: An IRES-cre cassette was inserted into exon 5. Expression of cre is induced in head mesoderm and mesoderm located dorsally to the cardiac cresent at E75. to E8.5, most mesoderm dorsal and lateral to the pharynx and head mesoderm at 4- and 6-somite stage, and mesoderm that virtually surrounds the pharynx at 8-somite stage in a pattern that is similar to Tbx1 expression. Author states that this is a null allele. (J:125024)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tbx1 (mouse) Summary of all recombinase alleles driven by Tbx1. Comparative matrix view of recombinase activities Alliance mouse Tbx1 gene page

Expression

In Mice Carrying this Mutation:	5 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tbx1 Mutation: 36 strains or lines available

References

• Original: J:125024 Huynh T, et al., A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac field. Genesis. 2007 Jul;45(7):470-5
• All: 26 reference(s)