Tg(Camk2a-DISC1)10Asaw
Transgene Detail

Summary

• Symbol: Tg(Camk2a-DISC1)10Asaw
• Name: transgene insertion 10, Akira Sawa
• MGI ID: MGI:3758077
• Synonyms: DN-DISC1, DN_DISC1
• Transgene: Tg(Camk2a-DISC1)10Asaw Location: unknown
• Alliance: Tg(Camk2a-DISC1)10Asaw page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Camk2a-DISC1)10Asaw expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DISC1 (27185)

  Disc1

  (MGI:2447658)

• Mutation details: The Camk2a promoter drives the expression of a truncated human DISC1 open reading frame that produces amino acids 1 through 597. This truncated protein is thought to function as a dominant negative. The transgene is expressed preferentially in neonatal stages, especially in pyramidal neurons of the dentate gyrus, and does not interfere with endogenous gene expression from Disc1. This is the low expressing line. (J:124683)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Two lines were created (lines 10 and 37) that display similar phenotypes.

References

• Original: J:124683 Hikida T, et al., From the Cover: Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14501-6
• All: 6 reference(s)