Pgm3^mld1
Chemically induced Allele Detail

Summary

• Symbol: Pgm3^mld1
• Name: phosphoglucomutase 3; multilineage defect 1
• MGI ID: MGI:3758645
• Gene: Pgm3 Location: Chr9:86436430-86453895 bp, - strand Genetic Position: Chr9, 46.58 cM, cytoband E3.2
• Alliance: Pgm3^mld1 page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A T to A transversion was induced by ENU mutagenisis in the fourth intron 14 bp upstream of exon 5. A complimentation assay was performed to determine the gene affected. While a transcript is detectable by RT-PCR the resulting protein has less than 1% of wild-type enzymatic activity in the testes, spleen, pancreas and heart. (J:125094)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pgm3 Mutation: 38 strains or lines available

References

• Original: J:125094 Greig KT, et al., Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development. Mol Cell Biol. 2007 Aug;27(16):5849-59
• All: 1 reference(s)