Tg(Th-SNCA*)1Mgsp
Transgene Detail

Summary

• Symbol: Tg(Th-SNCA*)1Mgsp
• Name: transgene insertion 1, Maria Grazia Spillantini
• MGI ID: MGI:3758646
• Synonyms: TgSyn120
• Transgene: Tg(Th-SNCA*)1Mgsp Location: unknown
• Alliance: Tg(Th-SNCA*)1Mgsp page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Th-SNCA*)1Mgsp expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Tg(Th-SNCA*)1Mgsp expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Th (25085)

  Th	(MGI:98735)

• Mutation details: The construct consisted of the sequence expressing human alpha-synuclein 1-120 which is truncated, lacking the final 20 amino acids inserted downstream of the rat tyrosine hydroxylase promoter Th in an expression vector. Vector sequences were removed and the linearized construct was microinjected into fertilized eggs. These mice were crossed to C57BL/6JOlaHsd mice which lack alpha-synuclein as a result of a spontaneous deletion of the alpha-SNCA locus. Immunoblotting demostrated high levels of alpha-synuclein 1-120 in the nigrostriatal pathway and the olfactory bulb in the line 1 founder. (J:108310)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:108310 Tofaris GK, et al., Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders. J Neurosci. 2006 Apr 12;26(15):3942-50
• All: 7 reference(s)