Ripply2^tm1.1Ysa
Targeted Allele Detail

Summary

• Symbol: Ripply2^tm1.1Ysa
• Name: ripply transcriptional repressor 2; targeted mutation 1, Yumiko Saga
• MGI ID: MGI:3758856
• Synonyms: Ripply2^-
• Gene: Ripply2 Location: Chr9:86897590-86901970 bp, + strand Genetic Position: Chr9, 46.69 cM
• Alliance: Ripply2^tm1.1Ysa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123846
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector with a floxed neo cassette replaced a portion of exon 1, introducing a termination codon right after the second translational initiation codon and creating a null allele. The floxed neo was excised by breeding the mice with transgenic mice expressing CAG-Cre. (J:123846)

Expression

In Mice Carrying this Mutation:	82 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ripply2 Mutation: 15 strains or lines available

References

• Original: J:123846 Morimoto M, et al., The negative regulation of Mesp2 by mouse Ripply2 is required to establish the rostro-caudal patterning within a somite. Development. 2007 Apr;134(8):1561-9
• All: 4 reference(s)