Inhba^tm3Zuk
Targeted Allele Detail

Summary

• Symbol: Inhba^tm3Zuk
• Name: inhibin beta-A; targeted mutation 3, Martin M Matzuk
• MGI ID: MGI:3758877
• Synonyms: betaA^flox
• Gene: Inhba Location: Chr13:16186436-16206206 bp, + strand Genetic Position: Chr13, 5.85 cM
• Alliance: Inhba^tm3Zuk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125354
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by loxP sites and neo cassette with a 3' lox P site was inserted downstream of exon 2. This exon encodes the entire mature domain of the protein and a conditional deletion of exon 2 would result in a null allele. (J:125354)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Inhba Mutation: 31 strains or lines available

Notes

ES cells used were generated in J:23923, ES cells AB2.1 (strain of origin 129S7/SvEvBrd-Hprt^b-m2) that contain the Inhba^tm1Zuk null allele.

References

• Original: J:125354 Pangas SA, et al., Intraovarian activins are required for female fertility. Mol Endocrinol. 2007 Oct;21(10):2458-71
• All: 6 reference(s)