Slc25a31^tm1Nte
Targeted Allele Detail

Summary

• Symbol: Slc25a31^tm1Nte
• Name: solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31; targeted mutation 1, Naohiro Terada
• MGI ID: MGI:3758940
• Synonyms: Ant4^-
• Gene: Slc25a31 Location: Chr3:40663301-40680525 bp, + strand Genetic Position: Chr3, 19.5 cM
• Alliance: Slc25a31^tm1Nte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125346
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 4 were replaced with an IRES-beta-gal-PGK-neo cassette. Lack of protein expression was confirmed by Western blot analysis on testies and heart tissue. Beta-galactosidase expression replicated endogenous gene expression. (J:125346)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc25a31 Mutation: 11 strains or lines available

References

• Original: J:125346 Brower JV, et al., Evolutionarily conserved Mammalian adenine nucleotide translocase 4 is essential for spermatogenesis. J Biol Chem. 2007 Oct 5;282(40):29658-66
• All: 7 reference(s)