Nlgn3^tm2.1Sud
Targeted Allele Detail

Summary

• Symbol: Nlgn3^tm2.1Sud
• Name: neuroligin 3; targeted mutation 2.1, Thomas C Sudhof
• MGI ID: MGI:3758960
• Gene: Nlgn3 Location: ChrX:100342785-100364956 bp, + strand Genetic Position: ChrX, 43.95 cM
• Alliance: Nlgn3^tm2.1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125344
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 2 and 3 were removed by cre-mediated recombination that also removed the neo cassette. The loss of protein expression was confirmed by western blot analysis using two antibodies (528B and 639B). (J:125344)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nlgn3 Mutation: 36 strains or lines available

References

• Original: J:125344 Tabuchi K, et al., A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science. 2007 Oct 5;318(5847):71-6
• All: 8 reference(s)