Cdk11b^Gt(XG836)Byg
Gene trapped Allele Detail

Summary

• Symbol: Cdk11b^Gt(XG836)Byg
• Name: cyclin dependent kinase 11B; gene trap XG836, BayGenomics
• MGI ID: MGI:3759055
• Synonyms: cdc2l^GT
• Gene: Cdk11b Location: Chr4:155709311-155734395 bp, + strand Genetic Position: Chr4, 86.73 cM
• Alliance: Cdk11b^Gt(XG836)Byg page

Mutation origin

• Mutant Cell Line: XG836
• Germline Transmission: Earliest citation of germline transmission: J:125424
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: The gene trap vector pGT1.8, containing a beta-geo cassette, was inserted into intron 12. Severe reduction in protein product was confirmed by RT-PCR and western blot. (J:125424)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XG836	CC183040 ; (MGI Seq Detail)	5' RACE	Chr4:155724269-155727028 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  16 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk11b Mutation: 48 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:125424 Chandramouli A, et al., Haploinsufficiency of the cdc2l gene contributes to skin cancer development in mice. Carcinogenesis. 2007 Sep;28(9):2028-35
• All: 2 reference(s)