Hace1^tm1Pngr
Targeted Allele Detail

Summary

• Symbol: Hace1^tm1Pngr
• Name: HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1; targeted mutation 1, Josef M Penninger
• MGI ID: MGI:3759063
• Synonyms: Hace1^-
• Gene: Hace1 Location: Chr10:45453925-45588441 bp, + strand Genetic Position: Chr10, 23.65 cM
• Alliance: Hace1^tm1Pngr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125183
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4, which encode the first two ankyrin repeats, were replaced with a neo cassette. The absence of transcript was confirmed by RT-PCR and northern blot analysis on kidney and embryonic fibroblasts. The absence of protein product was confirmed by western blot analysis on kidney tissue. (J:125183)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Hace1^tm1Pngr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hace1 Mutation: 55 strains or lines available

References

• Original: J:125183 Zhang L, et al., The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. Nat Med. 2007 Oct;13(9):1060-1069
• All: 7 reference(s)