Slc39a4^tm1Gka
Targeted Allele Detail

Summary

• Symbol: Slc39a4^tm1Gka
• Name: solute carrier family 39 (zinc transporter), member 4; targeted mutation 1, Glen K Andrews
• MGI ID: MGI:3759070
• Synonyms: ZIP4^-
• Gene: Slc39a4 Location: Chr15:76496583-76501579 bp, - strand Genetic Position: Chr15, 36.16 cM
• Alliance: Slc39a4^tm1Gka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125096
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An EGFP cassette and a floxed neo cassette were inserted exon 1. The floxed neo cassette was subsequently removed through a cross to a Cre deletor strain. Insertion of the EGFP was confirmed by PCR and the expression of EGFP. (J:125096)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc39a4 Mutation: 29 strains or lines available

References

• Original: J:125096 Dufner-Beattie J, et al., The mouse acrodermatitis enteropathica gene Slc39a4 (Zip4) is essential for early development and heterozygosity causes hypersensitivity to zinc deficiency. Hum Mol Genet. 2007 Jun 15;16(12):1391-9
• All: 1 reference(s)