Hdac6^tm1Pmt
Targeted Allele Detail

Summary

• Symbol: Hdac6^tm1Pmt
• Name: histone deacetylase 6; targeted mutation 1, Patrick Matthias
• MGI ID: MGI:3759271
• Gene: Hdac6 Location: ChrX:7796359-7814128 bp, - strand Genetic Position: ChrX, 3.58 cM
• Alliance: Hdac6^tm1Pmt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132629
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted between exon 7 and 8 and an additional loxP site was inserted downstream of exon 10. Transient cre expression was used to remove the neo cassette by cre-mediated recombination. (J:132629)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac6 Mutation: 17 strains or lines available

References

• Original: J:132629 Zhang Y, et al., Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Mol Cell Biol. 2008 Mar;28(5):1688-701
• All: 4 reference(s)