Gfra2^tm1Jmi
Targeted Allele Detail

Summary

• Symbol: Gfra2^tm1Jmi
• Name: glial cell line derived neurotrophic factor family receptor alpha 2; targeted mutation 1, Jeffrey Milbrandt
• MGI ID: MGI:3759280
• Synonyms: Gfra2^GFP
• Gene: Gfra2 Location: Chr14:71127560-71217278 bp, + strand Genetic Position: Chr14, 36.79 cM, cytoband D3-E1
• Alliance: Gfra2^tm1Jmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125236
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An EGFP cassette was inserted into the first coding exon disrupting the coding sequence of the rest of the open reading frame. The absence of transcript was confirmed by qRT-PCR on tissue from the tunica muscularis. (J:125236)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gfra2 Mutation: 23 strains or lines available

References

• Original: J:125236 McDonagh SC, et al., Role of glial cell-line derived neurotropic factor family receptor alpha2 in the actions of the glucagon-like peptides on the murine intestine. Am J Physiol Gastrointest Liver Physiol. 2007 Aug;293(2):G461-8
• All: 4 reference(s)