Dlgap3^tm1Gfng
Targeted Allele Detail

Summary

• Symbol: Dlgap3^tm1Gfng
• Name: DLG associated protein 3; targeted mutation 1, Guoping Feng
• MGI ID: MGI:3759300
• Synonyms: Sapap3^-
• Gene: Dlgap3 Location: Chr4:127062997-127130815 bp, + strand Genetic Position: Chr4, 61.33 cM
• Alliance: Dlgap3^tm1Gfng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125181
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 containing the translation initiation codon was replaced with a neo cassette. The absence of protein product was confirmed by western blot analysis of brain lysate and postsynaptic density fraction. (J:125181)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dlgap3 Mutation: 84 strains or lines available

References

• Original: J:125181 Welch JM, et al., Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. Nature. 2007 Aug 23;448(7156):894-900
• All: 25 reference(s)