Tg(Camk2a-cre/ERT2)2Gsc
Transgene Detail

Summary

• Symbol: Tg(Camk2a-cre/ERT2)2Gsc
• Name: transgene insertion 2, Gunther Schutz
• MGI ID: MGI:3759305
• Synonyms: CaMKCreER^T2, Tg(Camk2a-cre/ESR1)2Gsc
• Transgene: Tg(Camk2a-cre/ERT2)2Gsc Location: unknown
• Alliance: Tg(Camk2a-cre/ERT2)2Gsc page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Camk2a-cre/ERT2)2Gsc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Camk2a

• Mutation details: The Camk2a promoter was used to drive expression of a cre and human estrogen receptor fusion (cre/ESR1). Expression is inducible by tamoxifen and localizes to the neurons of the adult forebrain. (J:125230)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Camk2a (species not specified) Summary of all recombinase alleles driven by Camk2a. Comparative matrix view of recombinase activities

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Three lines were created (lines 1, 2 and 3) with 1, 2 and 4 copy numbers of the transgene, respectively. Line 2 was choosen as the representative line because while copy number affects the level of expression similar phenotypes are produced and the majority of the reporting in J:125230 focuses on line 2.

References

• Original: J:125230 Erdmann G, et al., Inducible gene inactivation in neurons of the adult mouse forebrain. BMC Neurosci. 2007;8:63
• All: 63 reference(s)