Ptges3^tm1Nkt
Targeted Allele Detail

Summary

• Symbol: Ptges3^tm1Nkt
• Name: prostaglandin E synthase 3; targeted mutation 1, Yoshihito Nakatani
• MGI ID: MGI:3759309
• Synonyms: cPGES/p23^-
• Gene: Ptges3 Location: Chr10:127894851-127913123 bp, + strand Genetic Position: Chr10, 76.39 cM
• Alliance: Ptges3^tm1Nkt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125188
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with a PGK-neo cassette to create a null allele. The absence of protein product was confirmed by western blot analysis on brian, skin, lung, heart and liver tissue. (J:125188)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptges3 Mutation: 43 strains or lines available

References

• Original: J:125188 Nakatani Y, et al., Knockout mice lacking cPGES/p23, a constitutively expressed PGE2 synthetic enzyme, are peri-natally lethal. Biochem Biophys Res Commun. 2007 Oct 19;362(2):387-92
• All: 1 reference(s)