Dmbx1^tm1Sse
Targeted Allele Detail

Summary

• Symbol: Dmbx1^tm1Sse
• Name: diencephalon/mesencephalon homeobox 1; targeted mutation 1, Susumu Seino
• MGI ID: MGI:3759315
• Synonyms: Dmbx1^-
• Gene: Dmbx1 Location: Chr4:115772316-115797123 bp, - strand Genetic Position: Chr4, 53.07 cM
• Alliance: Dmbx1^tm1Sse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125193
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 3 and all of exon 4 were replaced with a lacZ-neo cassette. Absence of transcript was confirmed by northern blot on E10.5 whole embryos with a probe corresponding to nucleotids +238 to +1082 of GenBank accession no. NM_130865. (J:125193)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dmbx1 Mutation: 20 strains or lines available

References

• Original: J:125193 Fujimoto W, et al., Dmbx1 is essential in agouti-related protein action. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15514-9
• All: 2 reference(s)