Cln3^tm1Blda
Targeted Allele Detail

Summary

• Symbol: Cln3^tm1Blda
• Name: CLN3 lysosomal/endosomal transmembrane protein, battenin; targeted mutation 1, Beverly L Davidson
• MGI ID: MGI:3759415
• Synonyms: Cln3^lacZ
• Gene: Cln3 Location: Chr7:126170571-126184991 bp, - strand Genetic Position: Chr7, 69.16 cM
• Alliance: Cln3^tm1Blda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125194
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Genomic sequence from the ATG in exon 1 through exons 8 was replaced with a beta-gal-pA and TKPneo cassette then knocked into the open reading frame to produce a null reporter allele. Expression of the lacZ was confirmed by X-gal assay and the absence of a transcript was confirmed RT-PCR. (J:125194)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cln3 Mutation: 38 strains or lines available

References

• Original: J:125194 Eliason SL, et al., A knock-in reporter model of Batten disease. J Neurosci. 2007 Sep 12;27(37):9826-34
• All: 8 reference(s)