B3gat1^tm1Tkaw
Targeted Allele Detail

Summary

• Symbol: B3gat1^tm1Tkaw
• Name: beta-1,3-glucuronyltransferase 1; targeted mutation 1, Toshisuke Kawasaki
• MGI ID: MGI:3759445
• Synonyms: GlcAT-P^-
• Gene: B3gat1 Location: Chr9:26644813-26672646 bp, + strand Genetic Position: Chr9, 11.49 cM, cytoband A4
• Alliance: B3gat1^tm1Tkaw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125254
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 and 5 were replaced with a neo cassette disrupting domains critical for glucoronyltransferasse activity to create a null allele. The absence of transcript was confirmed by a northern blot using mRNA extracted from the brains of 10 week old mice. (J:125254)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any B3gat1 Mutation: 14 strains or lines available

References

• Original: J:125254 Yamamoto S, et al., Mice deficient in nervous system-specific carbohydrate epitope HNK-1 exhibit impaired synaptic plasticity and spatial learning. J Biol Chem. 2002 Jul 26;277(30):27227-31
• All: 6 reference(s)