Robo2^tm1.1Rilm
Targeted Allele Detail

Summary

• Symbol: Robo2^tm1.1Rilm
• Name: roundabout guidance receptor 2; targeted mutation 1.1, Richard Maas
• MGI ID: MGI:3759448
• Synonyms: Robo2^del5
• Gene: Robo2 Location: Chr16:73688727-74208713 bp, - strand Genetic Position: Chr16, 42.17 cM
• Alliance: Robo2^tm1.1Rilm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125214
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 5 was removed by cre-mediated recombination. A marked reduction in transcript size and quantity was confirmed by RT-PCR and in situ hybridization. Authors state that this allele is a null allele. (J:125214)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Robo2 Mutation: 101 strains or lines available

References

• Original: J:125214 Lu W, et al., Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. Am J Hum Genet. 2007 Apr;80(4):616-32
• All: 14 reference(s)