Sufu^Gt(XB699)Byg
Gene trapped Allele Detail

Summary

• Symbol: Sufu^Gt(XB699)Byg
• Name: SUFU negative regulator of hedgehog signaling; gene trap XB699, BayGenomics
• MGI ID: MGI:3759455
• Synonyms: Sufu^-
• Gene: Sufu Location: Chr19:46385335-46477243 bp, + strand Genetic Position: Chr19, 38.85 cM
• Alliance: Sufu^Gt(XB699)Byg page

Mutation origin

• Mutant Cell Line: XB699
• Germline Transmission: Earliest citation of germline transmission: J:125534
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Hypomorph)
• Mutation: Insertion of gene trap vector Vector: pGT0pfs Vector Type: gene trap
• Mutation details: A beta-geo cassette was inserted into the last exon and 3'UTR to create a truncation in which nucleotides 1482-1639 are missing. The truncated protein lacks the GLI-interating region. LacZ staining was used to confirm the insertion of the gene trap vector. (J:125534)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XB699	CC156274 ; (MGI Seq Detail)	5' RACE	Chr19:46461733-46464084 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  23 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Sufu^Gt(XB699)Byg

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sufu Mutation: 59 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:125534 Lee Y, et al., Loss of suppressor-of-fused function promotes tumorigenesis. Oncogene. 2007 Sep 27;26(44):6442-7
• All: 5 reference(s)