Shh^tm3(cre)Chg
Targeted Allele Detail

Summary

• Symbol: Shh^tm3(cre)Chg
• Name: sonic hedgehog; targeted mutation 3, Chin Chiang
• MGI ID: MGI:3759540
• Synonyms: Shh^cre, Shh-Cre
• Gene: Shh Location: Chr5:28661838-28672099 bp, - strand Genetic Position: Chr5, 14.39 cM
• Alliance: Shh^tm3(cre)Chg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109101
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Shh^tm3(cre)Chg expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Shh (MGI:98297)

• Mutation details: The cre open reading frame was placed under the control of the endogenous promoter and abolished Shh function. (J:109101)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Shh (mouse) Summary of all recombinase alleles driven by Shh. Alliance mouse Shh gene page

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shh Mutation: 48 strains or lines available

References

• Original: J:109101 Li Y, et al., Cholesterol modification restricts the spread of Shh gradient in the limb bud. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6548-53
• All: 5 reference(s)