Cdk4^tm2.1Bbd
Targeted Allele Detail

Summary

• Symbol: Cdk4^tm2.1Bbd
• Name: cyclin dependent kinase 4; targeted mutation 2.1, Mariano Barbacid
• MGI ID: MGI:3759558
• Synonyms: Cdk4^-
• Gene: Cdk4 Location: Chr10:126899404-126903157 bp, + strand Genetic Position: Chr10, 74.5 cM, cytoband D3
• Alliance: Cdk4^tm2.1Bbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125217
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 2 through 4 and a loxP-flanked selection cassette were removed by Flpe-mediated recombination. Removal of the exons was confirmed by Southern blot. (J:125217)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdk4 Mutation: 58 strains or lines available

References

• Original: J:125217 Barriere C, et al., Mice thrive without Cdk4 and Cdk2. Mol Oncol. 2007 Jun;1(1):72-83
• All: 4 reference(s)