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Clca1tm1.1Lex
Targeted Allele Detail
Summary
Symbol: Clca1tm1.1Lex
Name: chloride channel accessory 1; targeted mutation 1.1, Lexicon Genetics
MGI ID: MGI:3759581
Synonyms: Gob-5-, GOB5-KO allele, GOB5-KO deletion allele
Gene: Clca1  Location: Chr3:144710298-144738537 bp, - strand  Genetic Position: Chr3, 69.26 cM
Alliance: Clca1tm1.1Lex page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:125158
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 7 was removed by cre-mediated recombination using a protamine-cre (line unspecified; background given as 129/SvEvBrd). Removal of the exon was confirmed by PCR. (J:125158)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Clca1 Mutation:  58 strains or lines available
References
Original:  J:125158 Long AJ, et al., Gob-5 contributes to goblet cell hyperplasia and modulates pulmonary tissue inflammation. Am J Respir Cell Mol Biol. 2006 Sep;35(3):357-65
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory