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Ppp2r3ctm1Imku
Targeted Allele Detail
Summary
Symbol: Ppp2r3ctm1Imku
Name: protein phosphatase 2, regulatory subunit B'', gamma; targeted mutation 1, Nobuo Sakaguchi
MGI ID: MGI:3759678
Synonyms: G5prF
Gene: Ppp2r3c  Location: Chr12:55327594-55350024 bp, - strand  Genetic Position: Chr12, 23.9 cM, cytoband C1
Alliance: Ppp2r3ctm1Imku page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:100706
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 1 and a floxed neo cassette downstream of exon 2. Insertion was confirmed by Southern blot analysis. Cre-mediated recombination can remove the first 2 exons and result in an absence of transcript, as confirmed by RT-PCR. (J:100706)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
involves: C57BL/6
 
Phenotypes:
Affected Systems
show or hide all annotated terms
 
cellular
decreased B cell proliferation
hematopoietic system
increased transitional stage B cell number
increased pro-B cell number
decreased B cell number
decreased immature B cell number
decreased transitional stage B cell number
decreased mature B cell number
decreased B-1a cell number
decreased follicular B cell number
decreased pre-B cell number
increased T cell number
small spleen
decreased spleen germinal center size
abnormal B cell activation
decreased B cell proliferation
immune system
increased transitional stage B cell number
increased pro-B cell number
decreased B cell number
decreased immature B cell number
decreased transitional stage B cell number
decreased mature B cell number
decreased B-1a cell number
decreased follicular B cell number
decreased pre-B cell number
increased T cell number
small spleen
decreased spleen germinal center size
abnormal B cell activation
decreased B cell proliferation
abnormal humoral immune response
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppp2r3c Mutation:  43 strains or lines available
References
Original:  J:100706 Xing Y, et al., Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis. J Exp Med. 2005 Sep 5;202(5):707-19
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory