Ppp2r3ctm1Imku
Targeted Allele Detail
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Symbol: |
Ppp2r3ctm1Imku |
Name: |
protein phosphatase 2, regulatory subunit B'', gamma; targeted mutation 1, Nobuo Sakaguchi |
MGI ID: |
MGI:3759678 |
Synonyms: |
G5prF |
Gene: |
Ppp2r3c Location: Chr12:55327594-55350024 bp, - strand Genetic Position: Chr12, 23.9 cM, cytoband C1
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Alliance: |
Ppp2r3ctm1Imku page
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Germline Transmission: |
Earliest citation of germline transmission:
J:100706
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neo cassette downstream of exon 2. Insertion was confirmed by Southern blot analysis. Cre-mediated recombination can remove the first 2 exons and result in an absence of transcript, as confirmed by RT-PCR.
(J:100706)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: C57BL/6 | |
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Phenotypes: |
Affected Systems |
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cellular
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√
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decreased B cell proliferation
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√
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hematopoietic system
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√
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increased transitional stage B cell number
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√
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increased pro-B cell number
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√
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decreased B cell number
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√
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decreased immature B cell number
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√
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decreased transitional stage B cell number
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√
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decreased mature B cell number
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√
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decreased B-1a cell number
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√
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decreased follicular B cell number
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√
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decreased pre-B cell number
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√
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increased T cell number
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√
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small spleen
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decreased spleen germinal center size
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√
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abnormal B cell activation
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√
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decreased B cell proliferation
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√
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immune system
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√
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increased transitional stage B cell number
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√
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increased pro-B cell number
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√
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decreased B cell number
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√
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decreased immature B cell number
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√
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decreased transitional stage B cell number
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√
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decreased mature B cell number
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√
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decreased B-1a cell number
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√
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decreased follicular B cell number
|
√
|
decreased pre-B cell number
|
√
|
increased T cell number
|
√
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small spleen
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√
|
decreased spleen germinal center size
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√
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abnormal B cell activation
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√
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decreased B cell proliferation
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√
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abnormal humoral immune response
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ppp2r3c Mutation: |
43 strains or lines available
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Original: |
J:100706 Xing Y, et al., Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis. J Exp Med. 2005 Sep 5;202(5):707-19 |
All: |
2 reference(s) |
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