Nup98^tm1Jvd
Targeted Allele Detail

Summary

• Symbol: Nup98^tm1Jvd
• Name: nucleoporin 98; targeted mutation 1, Jan M A van Deursen
• MGI ID: MGI:3759762
• Synonyms: NUP98^-
• Gene: Nup98 Location: Chr7:101768607-101859359 bp, - strand Genetic Position: Chr7, 54.71 cM
• Alliance: Nup98^tm1Jvd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125571
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 3 encoding amino acids 33 through 118 and part of intron 3 were replaced with a PGK-neo cassette. The absence of protein product was confirmed by quantitative western blot analysis using the alphaNUP98(151-221) antibody. (J:125571)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nup98 Mutation: 146 strains or lines available

References

• Original: J:125571 Wu X, et al., Disruption of the FG nucleoporin NUP98 causes selective changes in nuclear pore complex stoichiometry and function. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3191-6
• All: 2 reference(s)