Itgav^tm2Hyn
Targeted Allele Detail

Summary

• Symbol: Itgav^tm2Hyn
• Name: integrin alpha V; targeted mutation 2, Richard Hynes
• MGI ID: MGI:3759836
• Synonyms: alphav^flox
• Gene: Itgav Location: Chr2:83554796-83637261 bp, + strand Genetic Position: Chr2, 49.33 cM
• Alliance: Itgav^tm2Hyn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94376
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted at the 5' start of exon 4 and additional loxP site was inserted downstream of exon 4 to create a floxed allele. The neo cassette was removed by cre-mediated recombination (source not specified). Insertion was confirmed by PCR and Southern blot. (J:94376, J:125508)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Itga5^tm2Hyn/Itga5^tm2Hyn Itgav^tm2Hyn/Itgav^tm2Hyn Tg(H2-K1-tsA58)6Kio/0	involves: 129 * C57BL/6 * SJL
cn2	Gt(ROSA)26Sor^tm1Sho/0 Itga5^tm2Hyn/Itga5^tm1Hyn Itgav^tm2Hyn/Itgav^+ Tg(Tek-cre)1Ywa/0	involves: 129 * C57BL/6 * SJL
cn3	Gt(ROSA)26Sor^tm1Sho/0 Itga5^tm2Hyn/Itga5^tm1Hyn Itgav^tm1Hyn/Itgav^tm2Hyn Tg(Tek-cre)1Ywa/0	involves: 129 * C57BL/6 * SJL
cn4	Itgav^tm2Hyn/Itgav^tm2.1Hyn Cd19^tm1(cre)Cgn/Cd19^+	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * FVB
cn5	Itgav^tm2Hyn/Itgav^tm2.1Hyn Lyz2^tm1(cre)Ifo/Lyz2^+	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * FVB
cn6	Itgav^tm2Hyn/Itgav^tm2.1Hyn Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB * SJL
cn7	Itgav^tm2Hyn/Itgav^tm2.1Hyn Tg(GFAP-cre)#Gtm/0	involves: 129P2/OlaHsd * C57BL/6 * CBA
cn8	Itgav^tm2Hyn/Itgav^tm2.1Hyn Tg(Tek-cre)1Ywa/0	involves: 129P2/OlaHsd * C57BL/6 * SJL
cn9	Itgav^tm2Hyn/Itgav^tm2.1Hyn Tg(Tek-cre)1Ywa/?	involves: 129S2/SvPas * C57BL/6 * FVB * SJL

Phenotypes:

Affected Systems	cn1	cn2	cn3	cn4	cn5	cn6	cn7	cn8	cn9
show or hide all annotated terms
behavior/neurological						√
abnormal motor capabilities/coordination/movement						√
abnormal involuntary movement						√
ataxia						√
impaired coordination						√
impaired limb coordination						√
abnormal posture						√
abnormal gait						√
paraparesis						√
seizures						√
convulsive seizures						√
cardiovascular system		√	√			√	√	N
cardiovascular system phenotype								N
retroesophageal right subclavian artery			√
vascular ring			√
abnormal ascending aorta morphology			√
abnormal brain vasculature morphology						√
patent ductus arteriosus		√	√
ventricular septal defect		√	√
intracranial hemorrhage						√	√
cerebellum hemorrhage							√
intracerebral hemorrhage						√	√
spinal hemorrhage						√
cellular	√	√	√		√				√
patent ductus arteriosus		√	√
abnormal cell adhesion	√
abnormal dendritic cell differentiation									√
impaired macrophage phagocytosis					√				√
digestive/alimentary system				N	√				√
digestive/alimentary phenotype				N
abnormal intestinal epithelium morphology									√
crypts of Lieberkuhn abscesses									√
intestinal ulcer									√
increased intestinal adenocarcinoma incidence									√
large intestinal inflammation									√
colitis					√				√
endocrine/exocrine glands									√
crypts of Lieberkuhn abscesses									√
growth/size/body									√
weight loss									√
hematopoietic system					√				√
impaired macrophage phagocytosis					√				√
abnormal leukocyte morphology									√
abnormal dendritic cell differentiation									√
decreased regulatory T cell number									√
increased regulatory T cell number									√
homeostasis/metabolism									√
abnormal interferon level									√
abnormal interleukin level									√
abnormal tumor necrosis factor level									√
immune system					√	√			√
abnormal immune system morphology									√
abnormal leukocyte morphology									√
abnormal dendritic cell differentiation									√
decreased regulatory T cell number									√
increased regulatory T cell number									√
enlarged Peyer's patches									√
enlarged mesenteric lymph nodes									√
abnormal immune system physiology									√
impaired macrophage phagocytosis					√				√
abnormal interferon level									√
abnormal interleukin level									√
abnormal tumor necrosis factor level									√
increased autoantibody level					√				√
increased inflammatory response									√
large intestinal inflammation									√
colitis					√				√
increased susceptibility to bacterial infection induced morbidity/mortality						√
mortality/aging		√	√			√			√
increased susceptibility to bacterial infection induced morbidity/mortality						√
premature death						√			√
lethality throughout fetal growth and development, complete penetrance			√
postnatal lethality, incomplete penetrance		√
muscle						√
muscle phenotype						N
muscle hypertonia						√
neoplasm									√
increased intestinal adenocarcinoma incidence									√
nervous system						√	√
nervous system phenotype						N
seizures						√
convulsive seizures						√
abnormal brain vasculature morphology						√
intracranial hemorrhage						√	√
cerebellum hemorrhage							√
intracerebral hemorrhage						√	√
spinal hemorrhage						√
abnormal glial cell morphology						√
gliosis						√
abnormal embryonic/fetal subventricular zone morphology						√
axon degeneration						√
axonal dystrophy						√
demyelination						√
renal/urinary system						√
abnormal renal/urinary system physiology						√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

17 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Itgav^tm2Hyn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Itgav Mutation: 53 strains or lines available

References

• Original: J:94376 McCarty JH, et al., Selective ablation of {alpha}v integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development. 2005 Jan;132(1):165-176
• All: 35 reference(s)