Itgav^tm2.1Hyn
Targeted Allele Detail

Summary

• Symbol: Itgav^tm2.1Hyn
• Name: integrin alpha V; targeted mutation 2.1, Richard Hynes
• MGI ID: MGI:3759837
• Synonyms: alphav^-
• Gene: Itgav Location: Chr2:83554796-83637261 bp, + strand Genetic Position: Chr2, 49.33 cM
• Alliance: Itgav^tm2.1Hyn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94376
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 4 was removed by cre-mediated recombination to create a null allele. Absence of protein expression was confirmed by FACS analysis of macrophages and splenocytes. (J:94376, J:125508)

Expression

In Structures Affected by this Mutation:

17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgav Mutation: 54 strains or lines available

References

• Original: J:94376 McCarty JH, et al., Selective ablation of {alpha}v integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development. 2005 Jan;132(1):165-176
• All: 3 reference(s)