Mapkap1^tm1Bisu
Targeted Allele Detail

Summary

• Symbol: Mapkap1^tm1Bisu
• Name: mitogen-activated protein kinase associated protein 1; targeted mutation 1, Bing Su
• MGI ID: MGI:3759854
• Synonyms: SIN1^-
• Gene: Mapkap1 Location: Chr2:34296783-34514962 bp, + strand Genetic Position: Chr2, 22.84 cM
• Alliance: Mapkap1^tm1Bisu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125618
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2 and exon 3 were replaced with an EGFP-PGK-neo cassette. The lack of protein expression was confirmed by a western blot of extracts from mouse embryonic fibroblast cells using a Mapkap1-specific antibody K87. (J:125618)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapkap1 Mutation: 45 strains or lines available

References

• Original: J:125618 Jacinto E, et al., SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell. 2006 Oct 6;127(1):125-37
• All: 8 reference(s)