Adora2b^tm1Till
Targeted Allele Detail

Summary

• Symbol: Adora2b^tm1Till
• Name: adenosine A2b receptor; targeted mutation 1, Stephen Tilley
• MGI ID: MGI:3759856
• Synonyms: A2b^-
• Gene: Adora2b Location: Chr11:62139810-62157278 bp, + strand Genetic Position: Chr11, 37.96 cM, cytoband B2
• Alliance: Adora2b^tm1Till page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125297
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of the intron and all of exon 2 were replaced with a PGK-neo cassette to create a null allele. The absence of transcript was confirmed by RT-PCR and the absence of protein product was confirmed by western blot of protein extracts from the brain and kidney. (J:125297)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Adora2b Mutation: 20 strains or lines available

References

• Original: J:125297 Hua X, et al., Enhanced mast cell activation in mice deficient in the A2b adenosine receptor. J Exp Med. 2007 Jan 22;204(1):117-28
• All: 11 reference(s)