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Gab1tm5Wbm
Targeted Allele Detail
Summary
Symbol: Gab1tm5Wbm
Name: growth factor receptor bound protein 2-associated protein 1; targeted mutation 5, Walter Birchmeier
MGI ID: MGI:3759868
Synonyms: Gab1deltaShp2 (Y628F)
Gene: Gab1  Location: Chr8:81491067-81607148 bp, - strand  Genetic Position: Chr8, 38.47 cM, cytoband C3
Alliance: Gab1tm5Wbm page
Placenta development and muscle progenitor cell migration are disturbed in Gab1tm5Wbm/Gab1tm5Wbm mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:125303
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutation:    Nucleotide substitutions
 
Mutation detailsA cDNA encoding amino acids 198-695 with an amino acid substitution of tyrosine for phenylalanine at position 628 (Y628F) and a floxed neo cassette were knocked into exon d. The neo cassette was removed by cre-mediated recombination following a cross to a cre deleter strain (Tg(CMV-cre)1Cgn). The modification to the coding region is thought to interfere with protein-protein interactions with Shp2. Expression of the mutant protein confirmed by western blot analysis on protein extracts from E12 embryos was reduced by 40% to 50% relative to levels in wild-type mice. (J:125303)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gab1 Mutation:  78 strains or lines available
References
Original:  J:125303 Schaeper U, et al., Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15376-81
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory