About   Help   FAQ
Gab1tm5Wbm
Targeted Allele Detail
Summary
Symbol: Gab1tm5Wbm
Name: growth factor receptor bound protein 2-associated protein 1; targeted mutation 5, Walter Birchmeier
MGI ID: MGI:3759868
Synonyms: Gab1deltaShp2 (Y628F)
Gene: Gab1  Location: Chr8:81491067-81607148 bp, - strand  Genetic Position: Chr8, 38.47 cM, cytoband C3
Alliance: Gab1tm5Wbm page
Placenta development and muscle progenitor cell migration are disturbed in Gab1tm5Wbm/Gab1tm5Wbm mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:125303
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutation:    Nucleotide substitutions
 
Mutation detailsA cDNA encoding amino acids 198-695 with an amino acid substitution of tyrosine for phenylalanine at position 628 (Y628F) and a floxed neo cassette were knocked into exon d. The neo cassette was removed by cre-mediated recombination following a cross to a cre deleter strain (Tg(CMV-cre)1Cgn). The modification to the coding region is thought to interfere with protein-protein interactions with Shp2. Expression of the mutant protein confirmed by western blot analysis on protein extracts from E12 embryos was reduced by 40% to 50% relative to levels in wild-type mice. (J:125303)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gab1 Mutation:  78 strains or lines available
References
Original:  J:125303 Schaeper U, et al., Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15376-81
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory