Mapk8ip2^tm1Rjd
Targeted Allele Detail

Summary

• Symbol: Mapk8ip2^tm1Rjd
• Name: mitogen-activated protein kinase 8 interacting protein 2; targeted mutation 1, Roger J Davis
• MGI ID: MGI:3759989
• Synonyms: Jip2^-
• Gene: Mapk8ip2 Location: Chr15:89338114-89346650 bp, + strand Genetic Position: Chr15, 44.92 cM
• Alliance: Mapk8ip2^tm1Rjd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125318
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4 of the coding region were replaced with a neo cassette to create a null allele. Absence of a protein product was confirmed by western blot anaysis on protein extracts on brain lysates. (J:125318)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk8ip2 Mutation: 26 strains or lines available

References

• Original: J:125318 Kennedy NJ, et al., Requirement of JIP scaffold proteins for NMDA-mediated signal transduction. Genes Dev. 2007 Sep 15;21(18):2336-46
• All: 2 reference(s)